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M94A2019.TXT
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Document 2019
DOCN M94A2019
TI Host factors in the immunopathogenesis of human immunodeficiency virus
(HIV) disease.
DT 9412
AU Fauci AS; National Institute of Allergy and Infectious Diseases, NIH,;
Bethesda, MD 20892.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):4 (abstract no. PS2). Unique
Identifier : AIDSLINE ICA10/94370556
AB A complex array of immunopathogenic mechanisms that are multiphasic and
multifactorial are involved in the establishment and progression of HIV
disease. Following primary infection, an acute viremia occurs with wide
dissemination of HIV. During this early viremic phase, virus enters the
lymphoid tissue, trapped within the processes of follicular dendritic
cells. In addition, during this phase of primary infection certain
patients show major expansions of certain V beta subsets of CD8+ T cells
which are manifestations of responses to HIV and which may be associated
with both protective and harmful effects. Thus, events that occur soon
after initial infection with HIV are critical to the subsequent course
of HIV disease and may be extremely important in the control of the
progression of HIV infection. In addition, inappropriate immune
activation and elevated secretion of certain immunoregulatory cytokines
occur during HIV infection. These cytokines play a role in the
regulation of HIV expression in the tissues and, ultimately, influence
the course of disease. In studies of HIV-infected individuals who are
long term non-progressors despite up to 11 years of infection, it was
found that these patients have preserved lymph node architecture, low
viral burden and viral expression compared to individuals who are
infected for comparable periods of time, but who progress in their HIV
disease. The implications of host factors in the immunopathogenesis of
HIV disease will be discussed.
DE Antigens, CD8/IMMUNOLOGY Cytokines/IMMUNOLOGY/SECRETION Dendritic
Cells/IMMUNOLOGY Human HIV Infections/*IMMUNOLOGY Lymphocyte
Subsets/*IMMUNOLOGY Precipitating Factors T-Lymphocytes/IMMUNOLOGY
Viremia/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).